4fes: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fes]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FES FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fes]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FES FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0T9:(3S,8S,9S,10R,13S,14S,17R)-3-HYDROXY-10,13-DIMETHYL-17-[(2S,6S)-6-METHYL-3-OXOOCTAN-2-YL]-1,2,3,4,7,8,9,10,11,12,13,14,15,17-TETRADECAHYDRO-16H-CYCLOPENTA[A]PHENANTHREN-16-ONE'>0T9</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0T9:(3S,8S,9S,10R,13S,14S,17R)-3-HYDROXY-10,13-DIMETHYL-17-[(2S,6S)-6-METHYL-3-OXOOCTAN-2-YL]-1,2,3,4,7,8,9,10,11,12,13,14,15,17-TETRADECAHYDRO-16H-CYCLOPENTA[A]PHENANTHREN-16-ONE'>0T9</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fes OCA], [https://pdbe.org/4fes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fes RCSB], [https://www.ebi.ac.uk/pdbsum/4fes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fes ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fes OCA], [https://pdbe.org/4fes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fes RCSB], [https://www.ebi.ac.uk/pdbsum/4fes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fes ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/KES1_YEAST KES1_YEAST] Plays a role in ergosterol synthesis.
[https://www.uniprot.org/uniprot/KES1_YEAST KES1_YEAST] Plays a role in ergosterol synthesis.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have synthesized 16,22-diketocholesterol, a novel ligand for oxysterol-binding protein Osh4, and determined X-ray structure of the diketocholesterol in complex with Osh4. The X-ray structure shows that alpha7 helix of Osh4 assumes open conformation while the rest of Osh4, closed conformation, implying this diketocholesterol-bound Osh4 structure may represent a structural intermediate between the two conformations.
Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.,Koag MC, Cheun Y, Kou Y, Ouzon-Shubeita H, Min K, Monzingo AF, Lee S Steroids. 2013 Jun 10;78(9):938-944. doi: 10.1016/j.steroids.2013.05.016. PMID:23756172<ref>PMID:23756172</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4fes" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Oxysterol-binding protein homolog|Oxysterol-binding protein homolog]]
*[[Oxysterol-binding protein homolog|Oxysterol-binding protein homolog]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 15:23, 14 March 2024

Structure of OSH4 in complex with cholesterol analogs

4fes, resolution 2.00Å

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