8iow: Difference between revisions

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'''Unreleased structure'''


The entry 8iow is ON HOLD  until Paper Publication
==Cryo-EM structure of the sarilumab Fab/IL-6R complex==
 
<StructureSection load='8iow' size='340' side='right'caption='[[8iow]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
Authors: She, J., Chen, L., Wang, M.X.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8iow]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IOW FirstGlance]. <br>
Description: Cryo-EM structure of the sarilumab Fab/IL-6R complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: She, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iow OCA], [https://pdbe.org/8iow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iow RCSB], [https://www.ebi.ac.uk/pdbsum/8iow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iow ProSAT]</span></td></tr>
[[Category: Wang, M.X]]
</table>
[[Category: Chen, L]]
== Function ==
[https://www.uniprot.org/uniprot/IL6RA_HUMAN IL6RA_HUMAN] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>  Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen L]]
[[Category: She J]]
[[Category: Wang MX]]
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