8pee: Difference between revisions

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'''Unreleased structure'''


The entry 8pee is ON HOLD  until Paper Publication
==ABCB1 L335C mutant (mABCB1) in the inward facing state bound to AAC==
 
<StructureSection load='8pee' size='340' side='right'caption='[[8pee]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
Authors: Parey, K., Januliene, D., Gewering, T., Moeller, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8pee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PEE FirstGlance]. <br>
Description: ABCB1 L335C mutant (mABCB1) in the inward facing state bound to AAC
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JIZ:(4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione'>JIZ</scene>, <scene name='pdbligand=JJI:(4S,11S,18S)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione'>JJI</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
[[Category: Januliene, D]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pee OCA], [https://pdbe.org/8pee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pee RCSB], [https://www.ebi.ac.uk/pdbsum/8pee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pee ProSAT]</span></td></tr>
[[Category: Moeller, A]]
</table>
[[Category: Gewering, T]]
== Function ==
[[Category: Parey, K]]
[https://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Gewering T]]
[[Category: Januliene D]]
[[Category: Moeller A]]
[[Category: Parey K]]
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