8v8h: Difference between revisions
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==PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 4).== | |||
<StructureSection load='8v8h' size='340' side='right'caption='[[8v8h]], [[Resolution|resolution]] 3.58Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8v8h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V8H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.58Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YNZ:(2S)-N~1~-[(4P)-2-tert-butyl-4-methyl[4,5-bi-1,3-thiazol]-2-yl]pyrrolidine-1,2-dicarboxamide'>YNZ</scene>, <scene name='pdbligand=YO4:2-({(1R)-1-[2-(4,4-dimethylpiperidin-1-yl)-3,6-dimethyl-4-oxo-4H-1-benzopyran-8-yl]ethyl}amino)benzoic+acid'>YO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v8h OCA], [https://pdbe.org/8v8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v8h RCSB], [https://www.ebi.ac.uk/pdbsum/8v8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v8h ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Gunn RJ]] | |||
[[Category: Lawson JD]] | |||
Latest revision as of 08:22, 20 March 2024
PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 4).
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