8wu1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~8wu1~~ is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of CB1-beta-arrestin1 complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8wu1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WU1 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8WU1 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCA:methyl+N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate'>KCA</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8wu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wu1 OCA], [https://pdbe.org/8wu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wu1 RCSB], [https://www.ebi.ac.uk/pdbsum/8wu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wu1 ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/V2R_HUMAN V2R_HUMAN] Nephrogenic syndrome of inappropriate antidiuresis;Inappropriate antidiuretic hormone secretion syndrome;Nephrogenic diabetes insipidus. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/V2R_HUMAN V2R_HUMAN] Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.<ref>PMID:19440390</ref> [https://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bos taurus]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Cai C]]

[[Category: Liao Y]]

[[Category: Shen Q]]

[[Category: Zhang H]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8wu1 is ON HOLD  until Paper Publication
+==Cryo-EM structure of CB1-beta-arrestin1 complex==
+<StructureSection load='8wu1' size='340' side='right'caption='[[8wu1]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8wu1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WU1 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCA:methyl+N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate'>KCA</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wu1 OCA], [https://pdbe.org/8wu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wu1 RCSB], [https://www.ebi.ac.uk/pdbsum/8wu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wu1 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/V2R_HUMAN V2R_HUMAN] Nephrogenic syndrome of inappropriate antidiuresis;Inappropriate antidiuretic hormone secretion syndrome;Nephrogenic diabetes insipidus. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/V2R_HUMAN V2R_HUMAN] Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.<ref>PMID:19440390</ref> [https://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bos taurus]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Cai C]]
+[[Category: Liao Y]]
+[[Category: Shen Q]]
+[[Category: Zhang H]]