3w2z: Difference between revisions

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<StructureSection load='3w2z' size='340' side='right'caption='[[3w2z]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3w2z' size='340' side='right'caption='[[3w2z]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3w2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anabaena_7120 Anabaena 7120]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W2Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[3w2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_sp._PCC_7120_=_FACHB-418 Nostoc sp. PCC 7120 = FACHB-418]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W2Z FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vv4|3vv4]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">all1069 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=103690 Anabaena 7120])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w2z OCA], [https://pdbe.org/3w2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w2z RCSB], [https://www.ebi.ac.uk/pdbsum/3w2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w2z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w2z OCA], [https://pdbe.org/3w2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w2z RCSB], [https://www.ebi.ac.uk/pdbsum/3w2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w2z ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q8YXY7_NOSS1 Q8YXY7_NOSS1]
Cyanobacteriochromes are cyanobacterial tetrapyrrole-binding photoreceptors that share a bilin-binding GAF domain with photoreceptors of the phytochrome family. Cyanobacteriochromes are divided into many subclasses with distinct spectral properties. Among them, putative phototaxis regulators PixJs of Anabaena sp. PCC 7120 and Thermosynechococcus elongatus BP-1 (denoted as AnPixJ and TePixJ, respectively) are representative of subclasses showing red-green-type and blue/green-type reversible photoconversion, respectively. Here, we determined crystal structures for the AnPixJ GAF domain in its red-absorbing 15Z state (Pr) and the TePixJ GAF domain in its green-absorbing 15E state (Pg). The overall structure of these proteins is similar to each other and also similar to known phytochromes. Critical differences found are as follows: (i) the chromophore of AnPixJ Pr is phycocyanobilin in a C5-Z,syn/C10-Z,syn/C15-Z,anti configuration and that of TePixJ Pg is phycoviolobilin in a C10-Z,syn/C15-E,anti configuration, (ii) a side chain of the key aspartic acid is hydrogen bonded to the tetrapyrrole rings A, B and C in AnPixJ Pr and to the pyrrole ring D in TePixJ Pg, (iii) additional protein-chromophore interactions are provided by subclass-specific residues including tryptophan in AnPixJ and cysteine in TePixJ. Possible structural changes following the photoisomerization of the chromophore between C15-Z and C15-E are discussed based on the X-ray structures at 1.8 and 2.0-A resolution, respectively, in two distinct configurations.
 
Structures of cyanobacteriochromes from phototaxis regulators AnPixJ and TePixJ reveal general and specific photoconversion mechanism.,Narikawa R, Ishizuka T, Muraki N, Shiba T, Kurisu G, Ikeuchi M Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):918-23. doi:, 10.1073/pnas.1212098110. Epub 2012 Dec 19. PMID:23256156<ref>PMID:23256156</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3w2z" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Anabaena 7120]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ikeuchi, M]]
[[Category: Nostoc sp. PCC 7120 = FACHB-418]]
[[Category: Kurisu, G]]
[[Category: Ikeuchi M]]
[[Category: Muraki, N]]
[[Category: Kurisu G]]
[[Category: Narikawa, R]]
[[Category: Muraki N]]
[[Category: Shiba, T]]
[[Category: Narikawa R]]
[[Category: Cyanobacteriochrome]]
[[Category: Shiba T]]
[[Category: Gaf domain]]
[[Category: Photoreceptor]]
[[Category: Signaling protein]]

Latest revision as of 08:43, 20 March 2024

Crystal structure of the cyanobacterial protein

3w2z, resolution 1.80Å

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