1ff4: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ff4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FF4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ff4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FF4 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ff4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ff4 OCA], [https://pdbe.org/1ff4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ff4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ff4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ff4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ff4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ff4 OCA], [https://pdbe.org/1ff4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ff4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ff4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ff4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/3SIM2_DENAN 3SIM2_DENAN] Binds irreversibly to M1 (CHRM1) muscarinic acetylcholine receptors, and reveals a slightly weaker effect on M3 (CHRM3) receptors. The mechanism of toxin-receptor interaction comprises at least two steps. The first step is fast with no competition between the toxin and the antagonist. The second step is slow with formation of a more stable toxin-receptor complex and inhibition of the antagonist binding.<ref>PMID:7778123</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Dendroaspis angusticeps]] | [[Category: Dendroaspis angusticeps]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Gaucher JF]] | ||
[[Category: | [[Category: Le Du MH]] | ||
[[Category: Menez | [[Category: Menez A]] | ||
[[Category: Menez | [[Category: Menez R]] | ||
