8r02: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 8r02 is ON HOLD until Paper Publication~~

==Crystal structure of the retromer complex VPS29/VPS35 with the ligand bis-1,3-phenyl guanylhydrazone, 2a==

~~Authors: Milani, M., Fagnani, E.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[8r02]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R02 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8R02 FirstGlance].

~~Description:~~ Crystal structure of the retromer complex VPS29/VPS35 with the ligand bis-1,3-phenyl guanylhydrazone, 2a

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XFZ:Bis-1,3-phenyl+guanylhydrazon'>XFZ</scene></td></tr>

[[Category: ~~Milani, M~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r02 OCA], [https://pdbe.org/8r02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r02 RCSB], [https://www.ebi.ac.uk/pdbsum/8r02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r02 ProSAT]</td></tr>

[[Category: Fagnani, E]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/VPS29_HUMAN VPS29_HUMAN] Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro).<ref>PMID:15247922</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Fagnani E]]

[[Category: Milani M]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8r02 is ON HOLD  until Paper Publication
+==Crystal structure of the retromer complex VPS29/VPS35 with the ligand bis-1,3-phenyl guanylhydrazone, 2a==
+<StructureSection load='8r02' size='340' side='right'caption='[[8r02]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors: Milani, M., Fagnani, E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8r02]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R02 FirstGlance]. <br>
-Description: Crystal structure of the retromer complex VPS29/VPS35 with the ligand bis-1,3-phenyl guanylhydrazone, 2a
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XFZ:Bis-1,3-phenyl+guanylhydrazon'>XFZ</scene></td></tr>
-[[Category: Milani, M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r02 OCA], [https://pdbe.org/8r02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r02 RCSB], [https://www.ebi.ac.uk/pdbsum/8r02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r02 ProSAT]</span></td></tr>
-[[Category: Fagnani, E]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/VPS29_HUMAN VPS29_HUMAN] Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro).<ref>PMID:15247922</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Fagnani E]]
+[[Category: Milani M]]