8x6m: Difference between revisions
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==Crystal Structure of Glycerol Dehydrogenase in the Presence of NAD+ and Glycerol== | |||
<StructureSection load='8x6m' size='340' side='right'caption='[[8x6m]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8x6m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X6M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x6m OCA], [https://pdbe.org/8x6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x6m RCSB], [https://www.ebi.ac.uk/pdbsum/8x6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x6m ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLDA_ECOLI GLDA_ECOLI] Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions. In E.coli, an important role of GldA is also likely to regulate the intracellular level of dihydroxyacetone by catalyzing the reverse reaction, i.e. the conversion of dihydroxyacetone into glycerol. Possesses a broad substrate specificity, since it is also able to oxidize 1,2-propanediol and to reduce glycolaldehyde, methylglyoxal and hydroxyacetone into ethylene glycol, lactaldehyde and 1,2-propanediol, respectively.<ref>PMID:18179582</ref> <ref>PMID:18632294</ref> <ref>PMID:40950</ref> <ref>PMID:8132480</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Eom SH]] | |||
[[Category: Jin M]] | |||
[[Category: Kang JY]] | |||
[[Category: Kim H]] | |||
[[Category: Noh C]] | |||
[[Category: Park T]] | |||
[[Category: Yang J]] | |||
Latest revision as of 10:14, 27 March 2024
Crystal Structure of Glycerol Dehydrogenase in the Presence of NAD+ and Glycerol
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