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<SX load='6iij' size='340' side='right' viewer='molstar' caption='[[6iij]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
<SX load='6iij' size='340' side='right' viewer='molstar' caption='[[6iij]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6iij]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a10 Coxsackievirus a10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IIJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6IIJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[6iij]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A10 Coxsackievirus A10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IIJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6iij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iij OCA], [http://pdbe.org/6iij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iij RCSB], [http://www.ebi.ac.uk/pdbsum/6iij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iij ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iij OCA], [https://pdbe.org/6iij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iij RCSB], [https://www.ebi.ac.uk/pdbsum/6iij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iij ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/A0A1B3Z4Y8_9ENTO A0A1B3Z4Y8_9ENTO]
Coxsackievirus A10 (CV-A10) belongs to the Enterovirus species A and is a causative agent of hand, foot, and mouth disease. Here we present cryo-EM structures of CV-A10 mature virion and native empty particle (NEP) at 2.84 and 3.12 A, respectively. Our CV-A10 mature virion structure reveals a density corresponding to a lipidic pocket factor of 18 carbon atoms in the hydrophobic pocket formed within viral protein 1. By structure-guided high-throughput drug screening and subsequent verification in cell-based infection-inhibition assays, we identified four compounds that inhibited CV-A10 infection in vitro. These compounds represent a new class of anti-enteroviral drug leads. Notably, one of the compounds, ICA135, also exerted broad-spectrum inhibitory effects on a number of representative viruses from all four species (A-D) of human enteroviruses. Our findings should facilitate the development of broadly effective drugs and vaccines for enterovirus infections.


Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses.,Chen J, Ye X, Zhang XY, Zhu Z, Zhang X, Xu Z, Ding Z, Zou G, Liu Q, Kong L, Jiang W, Zhu W, Cong Y, Huang Z Cell Discov. 2019 Jan 15;5:4. doi: 10.1038/s41421-018-0073-7. eCollection 2019. PMID:30652025<ref>PMID:30652025</ref>
==See Also==
 
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6iij" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Coxsackievirus a10]]
[[Category: Coxsackievirus A10]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen, J H]]
[[Category: Chen JH]]
[[Category: Cong, Y]]
[[Category: Cong Y]]
[[Category: Huang, Z]]
[[Category: Huang Z]]
[[Category: Ye, X H]]
[[Category: Ye XH]]
[[Category: Mature virion]]
[[Category: Viral protein]]

Revision as of 10:33, 27 March 2024

Cryo-EM structure of CV-A10 mature virion

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