6l2w: Difference between revisions

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<StructureSection load='6l2w' size='340' side='right'caption='[[6l2w]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='6l2w' size='340' side='right'caption='[[6l2w]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6l2w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Microcystis_phage_mic1 Microcystis phage mic1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L2W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6L2W FirstGlance]. <br>
<table><tr><td colspan='2'>[[6l2w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Microcystis_phage_Mic1 Microcystis phage Mic1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L2W FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l2w OCA], [http://pdbe.org/6l2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l2w RCSB], [http://www.ebi.ac.uk/pdbsum/6l2w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l2w ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l2w OCA], [https://pdbe.org/6l2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l2w RCSB], [https://www.ebi.ac.uk/pdbsum/6l2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l2w ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/A0A4Y5TR47_9CAUD A0A4Y5TR47_9CAUD]
Cyanophages, widespread in aquatic systems, are a class of viruses that specifically infect cyanobacteria. Though they play important roles in modulating the homeostasis of cyanobacterial populations, little is known about the freshwater cyanophages, especially those hypothetical proteins of unknown function. Mic1 is a freshwater siphocyanophage isolated from the Lake Chaohu. It encodes three hypothetical proteins Gp65, Gp66 and Gp72, which share an identity of 61.6% ~ 83%. However, we find these three homologous proteins differ from each other in oligomeric state. Moreover, we solve the crystal structure of Gp72 at 2.3 a, which represents a novel fold in the alpha + beta class. Structural analyses combined with redox assays enable us to propose a model of disulfide bond mediated oligomerization for Gp72. Altogether, these findings provide structural and biochemical basis for further investigations on the freshwater cyanophage Mic1. This article is protected by copyright. All rights reserved.
 
Crystal structure of a novel fold protein Gp72 from the freshwater cyanophage Mic1.,Wang Y, Jin H, Yang F, Jiang YL, Zhao YY, Chen ZP, Li WF, Chen Y, Zhou CZ, Li Q Proteins. 2020 Apr 26. doi: 10.1002/prot.25896. PMID:32337767<ref>PMID:32337767</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6l2w" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Microcystis phage mic1]]
[[Category: Microcystis phage Mic1]]
[[Category: Chen, Y]]
[[Category: Chen Y]]
[[Category: Chen, Z P]]
[[Category: Chen ZP]]
[[Category: Jiang, Y L]]
[[Category: Jiang YL]]
[[Category: Jin, H]]
[[Category: Jin H]]
[[Category: Li, Q]]
[[Category: Li Q]]
[[Category: Li, W F]]
[[Category: Li WF]]
[[Category: Wang, Y]]
[[Category: Wang Y]]
[[Category: Yang, F]]
[[Category: Yang F]]
[[Category: Zhao, Y Y]]
[[Category: Zhao YY]]
[[Category: Zhou, C Z]]
[[Category: Zhou CZ]]
[[Category: Hypothetical protein]]
[[Category: Structural protein]]

Latest revision as of 10:45, 27 March 2024

Crystal structure of a novel fold protein Gp72 from the freshwater cyanophage Mic1

6l2w, resolution 2.29Å

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