6m3g: Difference between revisions
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==Crystal structure of human HPF1== | ==Crystal structure of human HPF1== | ||
<StructureSection load='6m3g' size='340' side='right'caption='[[6m3g]]' scene=''> | <StructureSection load='6m3g' size='340' side='right'caption='[[6m3g]], [[Resolution|resolution]] 1.57Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M3G FirstGlance]. <br> | <table><tr><td colspan='2'>[[6m3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M3G FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m3g OCA], [https://pdbe.org/6m3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m3g RCSB], [https://www.ebi.ac.uk/pdbsum/6m3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m3g ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m3g OCA], [https://pdbe.org/6m3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m3g RCSB], [https://www.ebi.ac.uk/pdbsum/6m3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m3g ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HPF1_HUMAN HPF1_HUMAN] Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine (PubMed:28190768, PubMed:29480802). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 (PubMed:30257210).<ref>PMID:27067600</ref> <ref>PMID:28190768</ref> <ref>PMID:29480802</ref> <ref>PMID:30257210</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Sun FH]] | [[Category: Sun FH]] | ||
[[Category: Yun CH]] | [[Category: Yun CH]] | ||
