7bu5: Difference between revisions

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====

==Crystal Structure of Human SLX4 and MUS81==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance].

<table><tr><td colspan='2'>[[7bu5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BU5 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7BU5 FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7bu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bu5 OCA], [https://pdbe.org/7bu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bu5 RCSB], [https://www.ebi.ac.uk/pdbsum/7bu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bu5 ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7bu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bu5 OCA], [https://pdbe.org/7bu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bu5 RCSB], [https://www.ebi.ac.uk/pdbsum/7bu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bu5 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/MUS81_HUMAN MUS81_HUMAN] Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:11741546</ref> <ref>PMID:12374758</ref> <ref>PMID:12686547</ref> <ref>PMID:12721304</ref> <ref>PMID:14617801</ref> <ref>PMID:15805243</ref> <ref>PMID:17289582</ref> <ref>PMID:19595721</ref> <ref>PMID:19596235</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: ~~Z-disk~~]]

[[Category: Lei M]]

[[Category: Wan B]]

[[Category: Wu J]]

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-====
+==Crystal Structure of Human SLX4 and MUS81==
-<StructureSection load='7bu5' size='340' side='right'caption='[[7bu5]]' scene=''>
+<StructureSection load='7bu5' size='340' side='right'caption='[[7bu5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7bu5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BU5 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bu5 OCA], [https://pdbe.org/7bu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bu5 RCSB], [https://www.ebi.ac.uk/pdbsum/7bu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bu5 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bu5 OCA], [https://pdbe.org/7bu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bu5 RCSB], [https://www.ebi.ac.uk/pdbsum/7bu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bu5 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/MUS81_HUMAN MUS81_HUMAN] Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:11741546</ref> <ref>PMID:12374758</ref> <ref>PMID:12686547</ref> <ref>PMID:12721304</ref> <ref>PMID:14617801</ref> <ref>PMID:15805243</ref> <ref>PMID:17289582</ref> <ref>PMID:19595721</ref> <ref>PMID:19596235</ref>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Z-disk]]
+[[Category: Lei M]]
+[[Category: Wan B]]
+[[Category: Wu J]]