7dl8: Difference between revisions

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<StructureSection load='7dl8' size='340' side='right'caption='[[7dl8]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
<StructureSection load='7dl8' size='340' side='right'caption='[[7dl8]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7dl8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DL8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7dl8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DL8 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALBA1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.459&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dl8 OCA], [https://pdbe.org/7dl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dl8 RCSB], [https://www.ebi.ac.uk/pdbsum/7dl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dl8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dl8 OCA], [https://pdbe.org/7dl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dl8 RCSB], [https://www.ebi.ac.uk/pdbsum/7dl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dl8 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q385X1_TRYB2 Q385X1_TRYB2]
Alba (Acetylation lowers binding affinity) domain is a small, dimeric nucleic acid-binding domain, which is widely distributed in archaea and numbers of eukaryotes. Alba domain containing proteins have been reported to be involved in many cellular processes, such as regulation of translation, maintaining genome stability, regulation of RNA processing and so on. In Trypanosoma brucei (T. brucei), there are four Alba proteins identified, which are named TbAlba1 to TbAlba4. However, the structure and function of TbAlba proteins are still unknown. Here, we solved the crystal structure of TbAlba1 to a resolution of 2.46 A. TbAlba1 adopts a similar Alba-fold, which comprises of four beta-strands (beta1-beta4) and three long alpha-helices (alpha1-alpha3). Furthermore, TbAlba1 displays some structural features quite different from other Alba proteins. These differences may imply the diverse biological roles of Alba family members.
 
Crystal structure of TbAlba1 from Trypanosoma brucei.,Gao J, Xiao C, Liao S, Tu X J Struct Biol. 2021 Jun 6;213(3):107751. doi: 10.1016/j.jsb.2021.107751. PMID:34107324<ref>PMID:34107324</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7dl8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gao, J]]
[[Category: Trypanosoma brucei]]
[[Category: Liao, S]]
[[Category: Gao J]]
[[Category: Tu, X]]
[[Category: Liao S]]
[[Category: Alba domain]]
[[Category: Tu X]]
[[Category: Rna binding]]
[[Category: Rna binding protein]]

Latest revision as of 10:53, 27 March 2024

Crystal structure of ALBA1 from Trypanosoma brucei

7dl8, resolution 2.46Å

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