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==Solution structure of the Albumin binding domain of Streptococcal Protein G==
==Solution structure of the Albumin binding domain of Streptococcal Protein G==
<StructureSection load='1gjs' size='340' side='right'caption='[[1gjs]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
<StructureSection load='1gjs' size='340' side='right'caption='[[1gjs]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1gjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strsp Strsp]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GJS FirstGlance]. <br>
<table><tr><td colspan='2'>[[1gjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GJS FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fcc|1fcc]], [[1fcl|1fcl]], [[1fd6|1fd6]], [[1gb4|1gb4]], [[1gjt|1gjt]], [[1ibx|1ibx]], [[1p7e|1p7e]], [[1p7f|1p7f]], [[2igg|2igg]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gjs OCA], [https://pdbe.org/1gjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gjs RCSB], [https://www.ebi.ac.uk/pdbsum/1gjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gjs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gjs OCA], [https://pdbe.org/1gjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gjs RCSB], [https://www.ebi.ac.uk/pdbsum/1gjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gjs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gjs ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gjs ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have determined the solution structure of an albumin binding domain of protein G, a surface protein of group C and G streptococci. We find that it folds into a left handed three-helix bundle similar to the albumin binding domain of protein PAB from Peptostreptococcus magnus. The two domains share 59% sequence identity, are thermally very stable, and bind to the same site on human serum albumin. The albumin binding site, the first determined for this structural motif known as the GA module, comprises residues spanning the first loop to the beginning of the third helix and includes the most conserved region of GA modules. The two GA modules have different affinities for albumin from different species, and their albumin binding patterns correspond directly to the host specificity of C/G streptococci and P. magnus, respectively. These studies of the evolution, structure, and binding properties of the GA module emphasize the power of bacterial adaptation and underline ecological and medical problems connected with the use of antibiotics.
Structure, specificity, and mode of interaction for bacterial albumin-binding modules.,Johansson MU, Frick IM, Nilsson H, Kraulis PJ, Hober S, Jonasson P, Linhult M, Nygren PA, Uhlen M, Bjorck L, Drakenberg T, Forsen S, Wikstrom M J Biol Chem. 2002 Mar 8;277(10):8114-20. Epub 2001 Dec 18. PMID:11751858<ref>PMID:11751858</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1gjs" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Protein G|Protein G]]
*[[Protein G|Protein G]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Strsp]]
[[Category: Streptococcus sp]]
[[Category: Bjorck, L]]
[[Category: Bjorck L]]
[[Category: Drakenberg, T]]
[[Category: Drakenberg T]]
[[Category: Forsen, S]]
[[Category: Forsen S]]
[[Category: Frick, I M]]
[[Category: Frick IM]]
[[Category: Hober, S]]
[[Category: Hober S]]
[[Category: Johansson, M U]]
[[Category: Johansson MU]]
[[Category: Jonasson, P]]
[[Category: Jonasson P]]
[[Category: Kraulis, P J]]
[[Category: Kraulis PJ]]
[[Category: Nilsson, H]]
[[Category: Nilsson H]]
[[Category: Nygren, A P]]
[[Category: Nygren AP]]
[[Category: Uhlen, M]]
[[Category: Uhlen M]]
[[Category: Wikstrom, M]]
[[Category: Wikstrom M]]
[[Category: Albumin binding]]
[[Category: Bacterial surface protein]]
[[Category: Immunoglobulin-binding protein]]
[[Category: Protein g]]
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