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==Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe==
==Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe==
<StructureSection load='1h7y' size='340' side='right'caption='[[1h7y]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='1h7y' size='340' side='right'caption='[[1h7y]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h6q|1h6q]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [https://pdbe.org/1h7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [https://www.ebi.ac.uk/pdbsum/1h7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [https://pdbe.org/1h7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [https://www.ebi.ac.uk/pdbsum/1h7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TCTP_SCHPO TCTP_SCHPO]] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).  
[https://www.uniprot.org/uniprot/TCTP_SCHPO TCTP_SCHPO] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h7y ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h7y ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and the human acute allergic response but whose intracellular biochemical function has remained elusive. We report here the solution structure of the TCTP from Schizosaccharomyces pombe, which, on the basis of sequence homology, defines the fold of the entire family. We show that TCTPs form a structural superfamily with the Mss4/Dss4 family of proteins, which bind to the GDP/GTP free form of Rab proteins (members of the Ras superfamily) and have been termed guanine nucleotide-free chaperones (GFCs). Mss4 also acts as a relatively inefficient guanine nucleotide exchange factor (GEF). We further show that the Rab protein binding site on Mss4 coincides with the region of highest sequence conservation in the TCTP family. This is the first link to any other family of proteins that has been established for the TCTP family and suggests the presence of a GFC/GEF at extremely high abundance in eukaryotic cells.
Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones.,Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ Nat Struct Biol. 2001 Aug;8(8):701-4. PMID:11473261<ref>PMID:11473261</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1h7y" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cbs 356]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Baxter, N J]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Craven, C J]]
[[Category: Baxter NJ]]
[[Category: Price, C]]
[[Category: Craven CJ]]
[[Category: Sedelnikova, S E]]
[[Category: Price C]]
[[Category: Thaw, P]]
[[Category: Sedelnikova SE]]
[[Category: Waltho, J P]]
[[Category: Thaw P]]
[[Category: Function unknown]]
[[Category: Waltho JP]]
[[Category: Tumor-associated protein]]

Revision as of 11:29, 27 March 2024

Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe

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