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==NMR Solution Structure of Murine CCL20/MIP-3a Chemokine==
==NMR Solution Structure of Murine CCL20/MIP-3a Chemokine==
<StructureSection load='1ha6' size='340' side='right'caption='[[1ha6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1ha6' size='340' side='right'caption='[[1ha6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ha6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HA6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ha6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HA6 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ha6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ha6 OCA], [https://pdbe.org/1ha6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ha6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ha6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ha6 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ha6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ha6 OCA], [https://pdbe.org/1ha6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ha6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ha6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ha6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CCL20_MOUSE CCL20_MOUSE]] Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial attracting lymphocytes and dendritic cells towards epithelial cells (By similarity).  
[https://www.uniprot.org/uniprot/CCL20_MOUSE CCL20_MOUSE] Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial attracting lymphocytes and dendritic cells towards epithelial cells (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ha6 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ha6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
CCL20/MIP-3alpha is a beta-chemokine expressed in the thymus, skin, and intestinal epithelial cells that exclusively binds and activates the CCR6 receptor in both mice and humans. The strict receptor binding specificity of CCL20 is exceptional; other chemokines and their receptors bind promiscuously with multiple partners. Toward determining the structural basis for the selective receptor specificity of CCL20, we have determined its three-dimensional structure by 1H NMR spectroscopy. CCL20 exhibits the same monomeric structure previously described for other chemokines: a three-stranded beta-sheet and an overlying alpha-helix. The CCL20 receptor selectivity could arise from the rigid conformation of the N-terminal DCCL motif as well as the groove between the N-loop and the beta2-beta3 hairpin, which is significantly narrower in CCL20 than in other chemokines. Similar structural features are seen in human beta-defensin 2, a small nonchemokine polypeptide reported to selectively bind and activate CCR6, which stresses their importance for the specific binding of both CCL20 and beta-defensin 2 to CCR6. CCL20's structure will be useful to design tools aimed to modulate its important biological functions.
NMR solution structure of murine CCL20/MIP-3alpha, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the beta-chemokine receptor CCR6.,Perez-Canadillas JM, Zaballos A, Gutierrez J, Varona R, Roncal F, Albar JP, Marquez G, Bruix M J Biol Chem. 2001 Jul 27;276(30):28372-9. Epub 2001 May 23. PMID:11373289<ref>PMID:11373289</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ha6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Albar, J P]]
[[Category: Mus musculus]]
[[Category: Bruix, M]]
[[Category: Albar JP]]
[[Category: Gutierrez, J]]
[[Category: Bruix M]]
[[Category: Marquez, G]]
[[Category: Gutierrez J]]
[[Category: Perez-Canadillas, J M]]
[[Category: Marquez G]]
[[Category: Roncal, F]]
[[Category: Perez-Canadillas JM]]
[[Category: Varona, R]]
[[Category: Roncal F]]
[[Category: Zaballos, A]]
[[Category: Varona R]]
[[Category: Ccl20/mip-3a]]
[[Category: Zaballos A]]
[[Category: Chemiokine]]
[[Category: Defensin]]
[[Category: Immune system]]
[[Category: Mouse]]

Revision as of 11:29, 27 March 2024

NMR Solution Structure of Murine CCL20/MIP-3a Chemokine

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