8pf4: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry 8pf4 is ON HOLD until 2025-06-15~~

==Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-methyl-1-(3-phenylpropyl)piperazin-1-ium==

~~Authors: Exertier, C., Ilari, A., Fiorillo, A., Antonelli, L.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[8pf4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PF4 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8PF4 FirstGlance].

~~Description:~~ Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-methyl-1-(3-phenylpropyl)piperazin-1-ium

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=YIA:~{N}-(4-fluorophenyl)-~{N}-[[5-[2-(4-fluorophenyl)ethylcarbamoyl]furan-2-yl]methyl]-4-methyl-4-(3-phenylpropyl)-1,4$l^{4}-diazinane-1-carboxamide'>YIA</scene></td></tr>

[[Category: ~~Fiorillo, A~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8pf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pf4 OCA], [https://pdbe.org/8pf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pf4 RCSB], [https://www.ebi.ac.uk/pdbsum/8pf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pf4 ProSAT]</td></tr>

[[Category: Antonelli, L]]

</table>

[[Category: ~~Ilari,~~ A]]

== Function ==

[[Category: ~~Exertier, C~~]]

[https://www.uniprot.org/uniprot/A0A3L6KZJ1_9TRYP A0A3L6KZJ1_9TRYP] Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase.[ARBA:ARBA00003667]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Trypanosoma brucei]]

[[Category: Antonelli L]]

[[Category: Exertier C]]

[[Category: Fiorillo A]]

[[Category: Ilari A]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8pf4 is ON HOLD  until 2025-06-15
+==Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-methyl-1-(3-phenylpropyl)piperazin-1-ium==
+<StructureSection load='8pf4' size='340' side='right'caption='[[8pf4]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
-Authors: Exertier, C., Ilari, A., Fiorillo, A., Antonelli, L.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8pf4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PF4 FirstGlance]. <br>
-Description: Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-methyl-1-(3-phenylpropyl)piperazin-1-ium
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=YIA:~{N}-(4-fluorophenyl)-~{N}-[[5-[2-(4-fluorophenyl)ethylcarbamoyl]furan-2-yl]methyl]-4-methyl-4-(3-phenylpropyl)-1,4$l^{4}-diazinane-1-carboxamide'>YIA</scene></td></tr>
-[[Category: Fiorillo, A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pf4 OCA], [https://pdbe.org/8pf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pf4 RCSB], [https://www.ebi.ac.uk/pdbsum/8pf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pf4 ProSAT]</span></td></tr>
-[[Category: Antonelli, L]]
+</table>
-[[Category: Ilari, A]]
+== Function ==
-[[Category: Exertier, C]]
+[https://www.uniprot.org/uniprot/A0A3L6KZJ1_9TRYP A0A3L6KZJ1_9TRYP] Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase.[ARBA:ARBA00003667]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Trypanosoma brucei]]
+[[Category: Antonelli L]]
+[[Category: Exertier C]]
+[[Category: Fiorillo A]]
+[[Category: Ilari A]]