6x8q: Difference between revisions
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==== | ==Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein PAPP peptide== | ||
<StructureSection load='6x8q' size='340' side='right'caption='[[6x8q]]' scene=''> | <StructureSection load='6x8q' size='340' side='right'caption='[[6x8q]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6x8q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_berghei_ANKA Plasmodium berghei ANKA]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X8Q FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x8q OCA], [https://pdbe.org/6x8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x8q RCSB], [https://www.ebi.ac.uk/pdbsum/6x8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x8q ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CSP_PLABA CSP_PLABA] Essential sporozoite protein (PubMed:6985745, PubMed:15630135, PubMed:16207248, PubMed:18005753, PubMed:21262960). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (PubMed:16207248, PubMed:21262960). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:6985745, PubMed:15630135, PubMed:18005753, PubMed:21262960). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (PubMed:18005753).<ref>PMID:15630135</ref> <ref>PMID:16207248</ref> <ref>PMID:18005753</ref> <ref>PMID:21262960</ref> <ref>PMID:6985745</ref> In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.<ref>PMID:18005753</ref> <ref>PMID:21262960</ref> | |||
==See Also== | |||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Plasmodium berghei ANKA]] | |||
[[Category: Julien JP]] | |||
[[Category: Thai E]] | |||
