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==Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus==
==Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus==
<StructureSection load='1k3k' size='340' side='right'caption='[[1k3k]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1k3k' size='340' side='right'caption='[[1k3k]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1k3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K3K FirstGlance]. <br>
<table><tr><td colspan='2'>[[1k3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K3K FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k3k OCA], [https://pdbe.org/1k3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k3k RCSB], [https://www.ebi.ac.uk/pdbsum/1k3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k3k ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k3k OCA], [https://pdbe.org/1k3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k3k RCSB], [https://www.ebi.ac.uk/pdbsum/1k3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k3k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q76RI8_HHV8 Q76RI8_HHV8]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k3k ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k3k ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has functional and sequence homology to the apoptotic Bcl-2 family of proteins [Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J. &amp; Chang, Y. (1997) Nat. Med. 3, 293-298]. The viral Bcl-2 protein promotes survival of infected cells and may contribute to the development of Kaposi sarcoma tumors [Boshoff, C. &amp; Chang, Y. (2001) Annu. Rev. Med. 52, 453-470]. Here we describe the solution structure of the viral Bcl-2 homolog from KSHV. Comparison of the KSHV Bcl-2 structure to that of Bcl-2 and Bcl-x(L) shows that although the overall fold is the same, there are key differences in the lengths of the helices and loops. Binding studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl-x(L) and Bcl-2, suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins.
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.,Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. PMID:11904405<ref>PMID:11904405</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1k3k" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hhv-8]]
[[Category: Human gammaherpesvirus 8]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fesik, S W]]
[[Category: Fesik SW]]
[[Category: Huang, Q]]
[[Category: Huang Q]]
[[Category: Olejniczak, E T]]
[[Category: Olejniczak ET]]
[[Category: Petros, A M]]
[[Category: Petros AM]]
[[Category: Virgin, H W]]
[[Category: Virgin HW]]
[[Category: Apoptosis]]
[[Category: Bcl-2]]
[[Category: Herpesvirus]]
[[Category: Solution structure]]

Revision as of 07:57, 3 April 2024

Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus

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