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==Solution Structure of the PPIase Domain from E. coli Trigger Factor==
==Solution Structure of the PPIase Domain from E. coli Trigger Factor==
<StructureSection load='1l1p' size='340' side='right'caption='[[1l1p]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
<StructureSection load='1l1p' size='340' side='right'caption='[[1l1p]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1l1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1P FirstGlance]. <br>
<table><tr><td colspan='2'>[[1l1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1P FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1p OCA], [https://pdbe.org/1l1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1p RCSB], [https://www.ebi.ac.uk/pdbsum/1l1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1p ProSAT], [https://www.topsan.org/Proteins/BSGI/1l1p TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1p OCA], [https://pdbe.org/1l1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1p RCSB], [https://www.ebi.ac.uk/pdbsum/1l1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1p ProSAT], [https://www.topsan.org/Proteins/BSGI/1l1p TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TIG_ECOLI TIG_ECOLI]] Involved in protein export. Acts as a chaperone by maintaining the newly synthesized secretory and non-secretory proteins in an open conformation. Binds to nascent polypeptide chains via ribosomal protein L23 (PubMed:12226666). Functions as a peptidyl-prolyl cis-trans isomerase in vitro, this activity is dispensible in vivo for chaperone activity.<ref>PMID:8633085</ref> <ref>PMID:8521806</ref> <ref>PMID:14726952</ref>
[https://www.uniprot.org/uniprot/TIG_ECOLI TIG_ECOLI] Involved in protein export. Acts as a chaperone by maintaining the newly synthesized secretory and non-secretory proteins in an open conformation. Binds to nascent polypeptide chains via ribosomal protein L23 (PubMed:12226666). Functions as a peptidyl-prolyl cis-trans isomerase in vitro, this activity is dispensible in vivo for chaperone activity.<ref>PMID:8633085</ref> <ref>PMID:8521806</ref> <ref>PMID:14726952</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Denisov A]]
[[Category: Structural genomic]]
[[Category: Ekiel I]]
[[Category: Denisov, A]]
[[Category: Gehring K]]
[[Category: Ekiel, I]]
[[Category: Ghandi S]]
[[Category: Gehring, K]]
[[Category: Kozlov G]]
[[Category: Ghandi, S]]
[[Category: Perreault A]]
[[Category: Kozlov, G]]
[[Category: Trempe J-F]]
[[Category: Perreault, A]]
[[Category: Wong M]]
[[Category: Trempe, J F]]
[[Category: Wong, M]]
[[Category: Bsgi]]
[[Category: Isomerase]]
[[Category: Mixed beta-alpha structure]]
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