VprBP: Difference between revisions
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== Function == | == Function == | ||
'''VprBP''' ('''VPR-binding protein''') is a HIV-1 WD40 protein is essential for DNA replication and embryonic development<ref>PMID:18606781</ref>. VprBP has intrinsic kinase activity and is capable of phosphorylating histone H2A. Recruitment of VprBP by Vpr is essential for HIV-1 VPR activity of initiating the host cell response cycle arresting its G(2) phase following mitosis<ref>PMID:17314515</ref>. VprBP interacts with merlin which is then recruited to the E3 ligase complex resulting in its polyubiquitination and consequently its proteasome-mediated degradation<ref>PMID:18332868</ref>. | '''VprBP''' ('''VPR-binding protein''') or '''DDB1- and CUL4-associated factor 1''' or '''DCAF1''' is a HIV-1 WD40 protein is essential for DNA replication and embryonic development<ref>PMID:18606781</ref>. VprBP has intrinsic kinase activity and is capable of phosphorylating histone H2A. Recruitment of VprBP by Vpr is essential for HIV-1 VPR activity of initiating the host cell response cycle arresting its G(2) phase following mitosis<ref>PMID:17314515</ref>. VprBP interacts with merlin which is then recruited to the E3 ligase complex resulting in its polyubiquitination and consequently its proteasome-mediated degradation<ref>PMID:18332868</ref>. | ||
== Relevance == | == Relevance == | ||
