Penams: Difference between revisions
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Penams are the primary skeleton structures that define the penicillin subclass of the broader β-lactam family of antibiotics and related compounds. They are bicyclic ring systems containing a β-lactam moiety fused with a five-member thiazolidine ring.<ref name="a1">PMID:5219821</ref> Due to ring strain and limitations on amide resonance, the structure is unstable and highly susceptible to catalytic cleavage at the amide bond.<ref>doi:10.1093/actrade/9780198759775.003.0005</ref> <scene name='10/1038837/Cv/3'>Benzylpenicillin (penicillin G)</scene> is the natural product parent that contains the penam structure. The β-lactam ring is in salmon. See also [https://en.wikipedia.org/wiki/Penam Penam]. | Penams are the primary skeleton structures that define the penicillin subclass of the broader β-lactam family of antibiotics and related compounds. They are bicyclic ring systems containing a β-lactam moiety fused with a five-member thiazolidine ring.<ref name="a1">PMID:5219821</ref> Due to ring strain and limitations on amide resonance, the structure is unstable and highly susceptible to catalytic cleavage at the amide bond.<ref>doi:10.1093/actrade/9780198759775.003.0005</ref> <scene name='10/1038837/Cv/3'>Benzylpenicillin (penicillin G)</scene> is the natural product parent that contains the penam structure. The β-lactam ring is in salmon. See also [https://en.wikipedia.org/wiki/Penam Penam]. | ||
*[[Ampicillin]] | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
