Ampicillin: Difference between revisions
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Ampicillin is in the penicillin group of beta-lactam antibiotics and is part of the aminopenicillin family. It is roughly equivalent to amoxicillin in terms of activity.<ref name="a7">[https://www.drugs.com/monograph/ampicillin.html "Ampicillin".] The American Society of Health-System Pharmacists. Archived from the original on 12 July 2015. Retrieved 1 August 2015.</ref> Ampicillin is able to penetrate gram-positive and some gram-negative bacteria. It differs from penicillin G, or benzylpenicillin, only by the presence of an amino group. This amino group, present on both ampicillin and amoxicillin, helps these antibiotics pass through the pores of the outer membrane of gram-negative bacteria, such as E. coli, Proteus mirabilis, Salmonella enterica, and Shigella.<ref name="a19">Hauser AR (2012). Antibiotic Basics for Clinicians: The ABCs of Choosing the Right Antibacterial Agent. Lippincott Williams & Wilkins. pp. 25–28. ISBN 978-1-4511-1221-4.</ref> | Ampicillin is in the penicillin group of beta-lactam antibiotics and is part of the aminopenicillin family. It is roughly equivalent to amoxicillin in terms of activity.<ref name="a7">[https://www.drugs.com/monograph/ampicillin.html "Ampicillin".] The American Society of Health-System Pharmacists. Archived from the original on 12 July 2015. Retrieved 1 August 2015.</ref> Ampicillin is able to penetrate gram-positive and some gram-negative bacteria. It differs from penicillin G, or benzylpenicillin, only by the presence of an amino group. This amino group, present on both ampicillin and amoxicillin, helps these antibiotics pass through the pores of the outer membrane of gram-negative bacteria, such as E. coli, Proteus mirabilis, Salmonella enterica, and Shigella.<ref name="a19">Hauser AR (2012). Antibiotic Basics for Clinicians: The ABCs of Choosing the Right Antibacterial Agent. Lippincott Williams & Wilkins. pp. 25–28. ISBN 978-1-4511-1221-4.</ref> | ||
''E. coli'' PBP structure shows a distinct <scene name='47/478544/Cv/5'>3 domain structures</scene> ([[2ex6]]). The <scene name='47/478544/Cv/6'>active site</scene> contains the <scene name='47/478544/Cv/7'>covalently bond between Ser62 and antibiotic ampicillin</scene><ref>PMID:16411754</ref>. Water molecules are shown as red spheres. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
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Revision as of 13:47, 3 April 2024
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