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H. sapiens Glucose-dependent Insulinotropic Polypeptide

spinqualitylabelsall models GIP Structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Introduction Glucose-dependent insulinotropic polypeptide (GIP) is a gastric inhibitory polypeptide. It is categorized as a incretin, which is a gut-based hormone that is secreted upon the ingestion of food. It is found in K cells in the upper small intestines of humans. History The idea of incretin began in 1902 after the discovery of secretin by Bayliss and Starling. Inspired by their discovery, Moore et al. hypothesized that there must be some kind of gut hormone that regulates the endocrine pancreas. His experiments showed that gut extracts in patients with diabetes have reduced amounts of sugars in their urine as a result of endocrine stimulation. In 1929, a French scientist named La Barre was able to purify incretin from gut extracts. The name incretin comes from INtestine seCRETion INsulin. Structure Overview GIP is a G-coupled receptor. It is composed of the alpha, beta, and gamma subunits. Function This is a default text for your page Mandy Bechman/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol to the rescue. Function Mechanism The mechanism of GIP begins with the ingestion of food. Disease One of the most promising treatments to GIP malfunction is Tirzepatide. Sequence Comparison Structural highlights Alanine converted to AIB This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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Mandy Bechman