Coatomer: Difference between revisions

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'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. ~~COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>.~~

'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1.

== Function ==

COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>.

COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>. COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>. Dilysine motifs on transmembrane proteins are recognised by COPI alpha and beta' subunits and packaged into COPI-coated vesicles for transport from Golgi to ER<ref>PMID:23481256</ref>.

== Disease ==

Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:3584149</ref>.

== Relevance ==

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 <StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Art-1 (cyan) (PDB entry [[5nzu]])' scene=>
-'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>.  Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1.  COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>.
+'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>.  Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1.
 == Function ==
-COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>.
+COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>.  COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>. Dilysine motifs on transmembrane proteins are recognised by COPI alpha and beta' subunits and packaged into COPI-coated vesicles for transport from Golgi to ER<ref>PMID:23481256</ref>.
 == Disease ==
 Mutations in COPI can result in osteoporosis, fractures and developmental delays.  Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:3584149</ref>.
 == Relevance ==