8qic: Difference between revisions
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==Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors== | |||
<StructureSection load='8qic' size='340' side='right'caption='[[8qic]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8qic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_IAI1 Escherichia coli IAI1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QIC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=VL0:2-oxidanyl-5-[[4-(phenylmethyl)phenyl]sulfamoyl]benzoic+acid'>VL0</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qic OCA], [https://pdbe.org/8qic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qic RCSB], [https://www.ebi.ac.uk/pdbsum/8qic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qic ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SYT_ECO8A SYT_ECO8A] Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).[HAMAP-Rule:MF_00184] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli IAI1]] | |||
[[Category: Large Structures]] | |||
[[Category: Parisini E]] | |||
[[Category: Rodriguez JA]] | |||
Latest revision as of 08:01, 10 April 2024
Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors
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