8qey: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8qey is ~~ON HOLD until Paper Publication~~

==Structure of human Asc1/CD98hc heteromeric amino acid transporter==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8qey]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QEY OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8QEY FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:Digitonin'>AJP</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8qey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qey OCA], [https://pdbe.org/8qey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qey RCSB], [https://www.ebi.ac.uk/pdbsum/8qey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qey ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/AAA1_HUMAN AAA1_HUMAN] Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity) (PubMed:10863037). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (By similarity). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (By similarity).[UniProtKB:P63115][UniProtKB:P63116]<ref>PMID:10863037</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Errasti-Murugarren E]]

[[Category: Llorca O]]

[[Category: Martinez-Molledo M]]

[[Category: Palacin M]]

[[Category: Rullo-Tubau J]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8qey is ON HOLD  until Paper Publication
+==Structure of human Asc1/CD98hc heteromeric amino acid transporter==
+<StructureSection load='8qey' size='340' side='right'caption='[[8qey]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8qey]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QEY FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:Digitonin'>AJP</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qey OCA], [https://pdbe.org/8qey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qey RCSB], [https://www.ebi.ac.uk/pdbsum/8qey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qey ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AAA1_HUMAN AAA1_HUMAN] Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity) (PubMed:10863037). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (By similarity). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (By similarity).[UniProtKB:P63115][UniProtKB:P63116]<ref>PMID:10863037</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Errasti-Murugarren E]]
+[[Category: Llorca O]]
+[[Category: Martinez-Molledo M]]
+[[Category: Palacin M]]
+[[Category: Rullo-Tubau J]]