1n1c: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 3: Line 3:
<StructureSection load='1n1c' size='340' side='right'caption='[[1n1c]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='1n1c' size='340' side='right'caption='[[1n1c]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1n1c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/'shewanella_massilia' 'shewanella massilia']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N1C FirstGlance]. <br>
<table><tr><td colspan='2'>[[1n1c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shewanella_massilia Shewanella massilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N1C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">torD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=76854 'Shewanella massilia'])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1c OCA], [https://pdbe.org/1n1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n1c RCSB], [https://www.ebi.ac.uk/pdbsum/1n1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n1c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1c OCA], [https://pdbe.org/1n1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n1c RCSB], [https://www.ebi.ac.uk/pdbsum/1n1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n1c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TORD_SHEMA TORD_SHEMA]] Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.  
[https://www.uniprot.org/uniprot/TORD_SHEMA TORD_SHEMA] Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 21: Line 20:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n1c ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n1c ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
TorD is the cytoplasmic chaperone involved in the maturation of the molybdoenzyme TorA prior to the translocation of the folded protein into the periplasm. The X-ray structure at 2.4 A resolution of the TorD dimer reveals extreme domain swapping between the two subunits. The all-helical architecture of the globular domains within the intertwined molecular dimer shows no similarity with known protein structures. According to sequence similarities, this new fold probably represents the architecture of the chaperones associated with the bacterial DMSO/TMAO reductases and also that of proteins of yet unknown functions. The occurrence of multiple oligomeric forms and the chaperone activity of both monomeric and dimeric TorD raise questions about the possible biological role of domain swapping in this protein.
A novel protein fold and extreme domain swapping in the dimeric TorD chaperone from Shewanella massilia.,Tranier S, Iobbi-Nivol C, Birck C, Ilbert M, Mortier-Barriere I, Mejean V, Samama JP Structure. 2003 Feb;11(2):165-74. PMID:12575936<ref>PMID:12575936</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1n1c" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Shewanella massilia]]
[[Category: Shewanella massilia]]
[[Category: Large Structures]]
[[Category: Birck C]]
[[Category: Birck, C]]
[[Category: Iobbi-Nivol C]]
[[Category: Iobbi-Nivol, C]]
[[Category: Mejean V]]
[[Category: Mejean, V]]
[[Category: Mortier-Barriere I]]
[[Category: Mortier-Barriere, I]]
[[Category: Samama J-P]]
[[Category: Samama, J P]]
[[Category: Tranier S]]
[[Category: Tranier, S]]
[[Category: 3d-domain swapping]]
[[Category: Chaperone]]
[[Category: Tord]]

Revision as of 08:44, 10 April 2024

Crystal Structure Of The Dimeric TorD Chaperone From Shewanella Massilia

1n1c, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1n1c&oldid=4125746"