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==Structure of the Plant Defensin PhD1 from Petunia Hybrida==
==Structure of the Plant Defensin PhD1 from Petunia Hybrida==
<StructureSection load='1n4n' size='340' side='right'caption='[[1n4n]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1n4n' size='340' side='right'caption='[[1n4n]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1n4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Petunia_x_hybrida Petunia x hybrida]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4N FirstGlance]. <br>
<table><tr><td colspan='2'>[[1n4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Petunia_x_hybrida Petunia x hybrida]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4N FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4n OCA], [https://pdbe.org/1n4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4n RCSB], [https://www.ebi.ac.uk/pdbsum/1n4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4n ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4n OCA], [https://pdbe.org/1n4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4n RCSB], [https://www.ebi.ac.uk/pdbsum/1n4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DEF1_PETHY DEF1_PETHY]] Plant defense peptide with antifungal activity against F.oxysporum and B.cinerea.  
[https://www.uniprot.org/uniprot/DEF1_PETHY DEF1_PETHY] Plant defense peptide with antifungal activity against F.oxysporum and B.cinerea.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4n ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4n ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of a novel plant defensin isolated from the flowers of Petunia hybrida has been determined by (1)H NMR spectroscopy. P. hybrida defensin 1 (PhD1) is a basic, cysteine-rich, antifungal protein of 47 residues and is the first example of a new subclass of plant defensins with five disulfide bonds whose structure has been determined. PhD1 has the fold of the cysteine-stabilized alphabeta motif, consisting of an alpha-helix and a triple-stranded antiparallel beta-sheet, except that it contains a fifth disulfide bond from the first loop to the alpha-helix. The additional disulfide bond is accommodated in PhD1 without any alteration of its tertiary structure with respect to other plant defensins. Comparison of its structure with those of classic, four-disulfide defensins has allowed us to identify a previously unrecognized hydrogen bond network that is integral to structure stabilization in the family.
Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds.,Janssen BJ, Schirra HJ, Lay FT, Anderson MA, Craik DJ Biochemistry. 2003 Jul 15;42(27):8214-22. PMID:12846570<ref>PMID:12846570</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1n4n" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Plant defensin|Plant defensin]]
*[[Plant defensin|Plant defensin]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Petunia x hybrida]]
[[Category: Petunia x hybrida]]
[[Category: Anderson, M A]]
[[Category: Anderson MA]]
[[Category: Craik, D J]]
[[Category: Craik DJ]]
[[Category: Janssen, B J.C]]
[[Category: Janssen BJC]]
[[Category: Lay, F T]]
[[Category: Lay FT]]
[[Category: Schirra, H J]]
[[Category: Schirra HJ]]
[[Category: Cysteine-stabilised alpha-beta motif]]
[[Category: Fifth disulfide bond]]
[[Category: Plant protein]]

Revision as of 08:45, 10 April 2024

Structure of the Plant Defensin PhD1 from Petunia Hybrida

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