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==Refined solution structure of the human TSG-6 Link module==
==Refined solution structure of the human TSG-6 Link module==
<StructureSection load='1o7b' size='340' side='right'caption='[[1o7b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1o7b' size='340' side='right'caption='[[1o7b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tsg|1tsg]], [[1o7c|1o7c]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [https://pdbe.org/1o7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [https://www.ebi.ac.uk/pdbsum/1o7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [https://pdbe.org/1o7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [https://www.ebi.ac.uk/pdbsum/1o7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TSG6_HUMAN TSG6_HUMAN]] Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.  
[https://www.uniprot.org/uniprot/TSG6_HUMAN TSG6_HUMAN] Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o7b ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o7b ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The solution structure of the Link module from human TSG-6, a hyaladherin with important roles in inflammation and ovulation, has been determined in both its free and hyaluronan-bound conformations. This reveals a well defined hyaluronan-binding groove on one face of the Link module that is closed in the absence of ligand. The groove is lined with amino acids that have been implicated in mediating the interaction with hyaluronan, including two tyrosine residues that appear to form essential intermolecular hydrogen bonds and two basic residues capable of supporting ionic interactions. This is the first structure of a non-enzymic hyaladherin in its active state, and identifies a ligand-induced conformational change that is likely to be conserved across the Link module superfamily. NMR and isothermal titration calorimetry experiments with defined oligosaccharides have allowed us to infer the minimum length of hyaluronan that can be accommodated within the binding site and its polarity in the groove; these data have been used to generate a model of the complex formed between the Link module and a hyaluronan octasaccharide.
The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding.,Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ J Biol Chem. 2003 Dec 5;278(49):49261-70. Epub 2003 Sep 11. PMID:12972412<ref>PMID:12972412</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1o7b" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Blundell, C D]]
[[Category: Blundell CD]]
[[Category: Campbell, I D]]
[[Category: Campbell ID]]
[[Category: Day, A J]]
[[Category: Day AJ]]
[[Category: Kahmann, J D]]
[[Category: Kahmann JD]]
[[Category: Pickford, A R]]
[[Category: Pickford AR]]
[[Category: Teriete, P]]
[[Category: Teriete P]]
[[Category: Carbohydrate-binding domain]]
[[Category: Cell adhesion]]
[[Category: Glycoprotein]]
[[Category: Hyaluronan-binding domain]]
[[Category: Link module]]
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