User:Mandy Bechman/Sandbox 1: Difference between revisions
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The idea of incretin began in 1902 after the discovery of secretin by Bayliss and Starling. Inspired by their discovery, Moore et al. hypothesized that there must be some kind of gut hormone that regulates the endocrine pancreas. His experiments showed that gut extracts in patients with diabetes have reduced amounts of sugars in their urine as a result of endocrine stimulation. In 1929, a French scientist named La Barre was able to purify incretin from gut extracts. The name incretin comes from INtestine seCRETion INsulin.<ref name="Seino"/> | The idea of incretin began in 1902 after the discovery of secretin by Bayliss and Starling. Inspired by their discovery, Moore et al. hypothesized that there must be some kind of gut hormone that regulates the endocrine pancreas. His experiments showed that gut extracts in patients with diabetes have reduced amounts of sugars in their urine as a result of endocrine stimulation. In 1929, a French scientist named La Barre was able to purify incretin from gut extracts. The name incretin comes from INtestine seCRETion INsulin.<ref name="Seino"/> | ||
==Structure Overview== | ==Structure Overview== | ||
GIP is a G-coupled receptor. It is composed of the alpha, beta, and gamma <scene name='10/1038867/Structure_overview/ | GIP is a G-coupled receptor. It is composed of the alpha, beta, and gamma <scene name='10/1038867/Structure_overview/5'>subunits</scene>. | ||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020673/ Function] | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020673/ Function] | ||
