Emily Berkman/Sandbox 2: Difference between revisions

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==T9==

Threonine 9 is an essential residue for the stabilization of amylin in the receptor. Threonine side chains are polar which allows them to hydrogen bond with other nearby polar groups, which can lead to extensive networks of interactions. This is seen in amylin at T9. T9 interacts with the <scene name='10/1038871/T9_main_chain/7'>main chain atoms</scene> of Y191, M230, I380, and H381 of the [https://en.wikipedia.org/wiki/Calcitonin_receptor calcitonin receptor] and many surrounding water molecules, but it also interacts with the <scene name='10/1038871/T9_network/1'>side chain atoms</scene> of S159, N194, S195, H226, N233, and Q383. All of these interactions create a very strong interaction between amylin and the receptor. The water network also helps stabilize the active receptor conformation. <ref name="Cao">PMID:35324283</ref>

Threonine 9 is an essential residue for the stabilization of amylin in the receptor. Threonine side chains are polar which allows them to hydrogen bond with other nearby polar groups, which can lead to extensive networks of interactions. This is seen in amylin at T9. T9 interacts with the <scene name='10/1038871/T9_main_chain/8'>main chain atoms</scene> of Y191, M230, I380, and H381 of the [https://en.wikipedia.org/wiki/Calcitonin_receptor calcitonin receptor] and many surrounding water molecules, but it also interacts with the <scene name='10/1038871/T9_network/4'>side chain atoms</scene> of S159, N194, S195, H226, N233, and Q383. All of these interactions create a very strong interaction between amylin and the receptor. The water network also helps stabilize the active receptor conformation. <ref name="Cao">PMID:35324283</ref>

Emily Berkman/Sandbox 2: Difference between revisions

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Revision as of 18:55, 11 April 2024 view source Emily Berkman (talk \| contribs) 50 edits No edit summary ← Older edit		Revision as of 19:07, 16 April 2024 view source Emily Berkman (talk \| contribs) 50 edits No edit summary Newer edit →
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	==T9==		==T9==
	Threonine 9 is an essential residue for the stabilization of amylin in the receptor. Threonine side chains are polar which allows them to hydrogen bond with other nearby polar groups, which can lead to extensive networks of interactions. This is seen in amylin at T9. T9 interacts with the <scene name='10/1038871/T9_main_chain/7'>main chain atoms</scene> of Y191, M230, I380, and H381 of the [https://en.wikipedia.org/wiki/Calcitonin_receptor calcitonin receptor] and many surrounding water molecules, but it also interacts with the <scene name='10/1038871/T9_network/1'>side chain atoms</scene> of S159, N194, S195, H226, N233, and Q383. All of these interactions create a very strong interaction between amylin and the receptor. The water network also helps stabilize the active receptor conformation. <ref name="Cao">PMID:35324283</ref>		Threonine 9 is an essential residue for the stabilization of amylin in the receptor. Threonine side chains are polar which allows them to hydrogen bond with other nearby polar groups, which can lead to extensive networks of interactions. This is seen in amylin at T9. T9 interacts with the <scene name='10/1038871/T9_main_chain/8'>main chain atoms</scene> of Y191, M230, I380, and H381 of the [https://en.wikipedia.org/wiki/Calcitonin_receptor calcitonin receptor] and many surrounding water molecules, but it also interacts with the <scene name='10/1038871/T9_network/4'>side chain atoms</scene> of S159, N194, S195, H226, N233, and Q383. All of these interactions create a very strong interaction between amylin and the receptor. The water network also helps stabilize the active receptor conformation. <ref name="Cao">PMID:35324283</ref>