8ki4: Difference between revisions
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==Crystal structure of human HSP90 in intermediate state== | |||
<StructureSection load='8ki4' size='340' side='right'caption='[[8ki4]], [[Resolution|resolution]] 1.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8ki4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KI4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
[[Category: Bai | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ki4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ki4 OCA], [https://pdbe.org/8ki4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ki4 RCSB], [https://www.ebi.ac.uk/pdbsum/8ki4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ki4 ProSAT]</span></td></tr> | ||
[[Category: Xu | </table> | ||
[[Category: Zhang | == Function == | ||
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bai F]] | |||
[[Category: Xu C]] | |||
[[Category: Zhang XL]] | |||
Latest revision as of 05:27, 17 April 2024
Crystal structure of human HSP90 in intermediate state
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