8wcr: Difference between revisions
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==Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in open state== | |||
<StructureSection load='8wcr' size='340' side='right'caption='[[8wcr]], [[Resolution|resolution]] 2.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8wcr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WCR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.74Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wcr OCA], [https://pdbe.org/8wcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wcr RCSB], [https://www.ebi.ac.uk/pdbsum/8wcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wcr ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gloeobacter violaceus]] | |||
[[Category: Large Structures]] | |||
[[Category: Basak S]] | |||
[[Category: Bharambe N]] | |||
[[Category: Li Z]] | |||
Latest revision as of 05:31, 17 April 2024
Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in open state
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