User:Brynn Baker/Sandbox1: Difference between revisions
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=== Amylin Binding === | === Amylin Binding === | ||
Y37 of amylin, the C-terminal residue, forms hydrogen bonds with <scene name='10/1037520/Y37_and_e101_ramp2/1'>E101 in RAMP2</scene> or <scene name='10/1037520/Y37_and_e74_ramp3/2'>E74 in RAMP3</scene>. It also forms van der Waals interactions with <scene name='10/1037520/Y37_and_f111_ramp2/2'>F111 of RAMP2</scene> or W84 and P85 in both <scene name='10/1037520/Y37_and_ramp1/1'>RAMP1</scene> and RAMP3. Uniquely, in RAMP3, W84 can adopt two conformations in RAMP3; one of which lies closer to Y37 and the other aligns almost perfectly with W84’s placement in RAMP1<ref name="Cao">PMID:35324283</ref>. | Y37 of amylin, the C-terminal residue, forms hydrogen bonds with <scene name='10/1037520/Y37_and_e101_ramp2/1'>E101 in RAMP2</scene> or <scene name='10/1037520/Y37_and_e74_ramp3/2'>E74 in RAMP3</scene>. It also forms van der Waals interactions with <scene name='10/1037520/Y37_and_f111_ramp2/2'>F111 of RAMP2</scene> or W84 and P85 in both <scene name='10/1037520/Y37_and_ramp1/1'>RAMP1</scene> and <scene name='10/1037520/Y37_and_ramp3/1'>RAMP3</scene>. Uniquely, in RAMP3, W84 can adopt two conformations in RAMP3; one of which lies closer to Y37 and the other aligns almost perfectly with W84’s placement in RAMP1<ref name="Cao">PMID:35324283</ref>. | ||
== Amylin Receptor Functional Overview == | == Amylin Receptor Functional Overview == | ||
