User:Brynn Baker/Sandbox1: Difference between revisions
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<scene name='10/1037520/Hydrophobic_pocket/6'>Y37</scene> on the C-terminus of the amylin peptide has extensive van der Waals interactions with the CT and RAMP3. The pi stacking and hydrophobic interactions increase the affinity and interactions between the amylin peptide, CT, and RAMP3, aiding in their association. | <scene name='10/1037520/Hydrophobic_pocket/6'>Y37</scene> on the C-terminus of the amylin peptide has extensive van der Waals interactions with the CT and RAMP3. The pi stacking and hydrophobic interactions increase the affinity and interactions between the amylin peptide, CT, and RAMP3, aiding in their association. | ||
=== Amidated C-Terminus === | === Amidated C-Terminus === | ||
Y37 of amylin is amidated. The <scene name='10/ | Y37 of amylin is amidated. The <scene name='10/1038871/Amidated_cterm/1'>amide group forms a hydrogen bond with the backbone of S129</scene> on the calcitonin receptor. All biological activity was lost when this amide group was experimentally removed<ref name="Cao">PMID:35324283</ref>. | ||
=== T6 === | === T6 === | ||
