User:Mandy Bechman/Sandbox 1: Difference between revisions

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In GIP,  residue 2 is an <scene name='10/1038867/Alanine_2_-_gip/3'>alanine</scene> but in Tirzepatide, the residue changes to <scene name='10/1038867/Tirzepatide_-_aib/2'>AIB</scene>. Residue 2 is where DPP4 recognizes GIP in order to cleave and inactivate the hormone. When the residue is changed, it is no longer recognized by DPP4 because AIB is a noncoding residue, resulting in continuous signaling to the cell.  
In GIP,  residue 2 is an <scene name='10/1038867/Alanine_2_-_gip/3'>alanine</scene> but in Tirzepatide, the residue changes to <scene name='10/1038867/Tirzepatide_-_aib/2'>AIB</scene>. Residue 2 is where DPP4 recognizes GIP in order to cleave and inactivate the hormone. When the residue is changed, it is no longer recognized by DPP4 because AIB is a noncoding residue, resulting in continuous signaling to the cell.  


This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.


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