Sandbox324: Difference between revisions
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The role in the body this would play based on results. Any potential implications of the enzyme if disrupted based on findings and related enzymes. | The role in the body this would play based on results. Any potential implications of the enzyme if disrupted based on findings and related enzymes. | ||
This protein belongs to the esterase family and expresses alpha/beta-hydrolase activity. Esterases are broadly defined as hydrolases that split ester, amide, and/or thioester bonds in certain compounds that cause prodrug activation and/or detoxification.<ref>Fukami, T.; Yokoi, T. The Emerging Role of Human Esterases. Drug Metabolism and Pharmacokinetics 2012, 27 (5), 466–477. https://doi.org/10.2133/dmpk.dmpk-12-rv-042.</ref> | This protein belongs to the esterase family and expresses alpha/beta-hydrolase activity. Esterases are broadly defined as hydrolases that split ester, amide, and/or thioester bonds in certain compounds that cause prodrug activation and/or detoxification.<ref>Fukami, T.; Yokoi, T. The Emerging Role of Human Esterases. Drug Metabolism and Pharmacokinetics 2012, 27 (5), 466–477. https://doi.org/10.2133/dmpk.dmpk-12-rv-042.</ref> The ability of esterases to hydrolyze various drugs make them an important component in drug metabolism<ref>Fukami, T.; Yokoi, T. The Emerging Role of Human Esterases. Drug Metabolism and Pharmacokinetics 2012, 27 (5), 466–477. https://doi.org/10.2133/dmpk.dmpk-12-rv-042.</ref>. | ||
== Proposed Function == | == Proposed Function == | ||
