8otv: Difference between revisions
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==Crystal structure of NUDT14 complexed with novel compound== | |||
<StructureSection load='8otv' size='340' side='right'caption='[[8otv]], [[Resolution|resolution]] 1.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8otv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OTV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=W0O:1-(1-methylpiperidin-4-yl)-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine'>W0O</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8otv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8otv OCA], [https://pdbe.org/8otv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8otv RCSB], [https://www.ebi.ac.uk/pdbsum/8otv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8otv ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: Brennan | [https://www.uniprot.org/uniprot/NUD14_HUMAN NUD14_HUMAN] Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose. | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Balikci E]] | |||
[[Category: Bountra C]] | |||
[[Category: Bradshaw W]] | |||
[[Category: Brennan PE]] | |||
[[Category: Feyerherm C]] | |||
[[Category: Huber K]] | |||
[[Category: Seupel R]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 06:20, 1 May 2024
Crystal structure of NUDT14 complexed with novel compound
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