8ou2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 1: Line 1:
'''Unreleased structure'''


The entry 8ou2 is ON HOLD  until Paper Publication
==Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor==
 
<StructureSection load='8ou2' size='340' side='right'caption='[[8ou2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
Authors: Balikci, E., Ni, X., Bountra, C., von Delft, F., Huber, K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ou2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OU2 FirstGlance]. <br>
Description: Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=W2W:7-(1-cyclopropylpyrazol-4-yl)-2-[[2-fluoranyl-4-(4-methylpiperazin-1-yl)sulfonyl-phenyl]amino]-3-methyl-pyrido[1,2-a]pyrimidin-4-one'>W2W</scene></td></tr>
[[Category: Ni, X]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ou2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ou2 OCA], [https://pdbe.org/8ou2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ou2 RCSB], [https://www.ebi.ac.uk/pdbsum/8ou2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ou2 ProSAT]</span></td></tr>
[[Category: Huber, K]]
</table>
[[Category: Balikci, E]]
== Function ==
[[Category: Von Delft, F]]
[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
[[Category: Bountra, C]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Balikci E]]
[[Category: Bountra C]]
[[Category: Huber K]]
[[Category: Ni X]]
[[Category: Von Delft F]]
Retrieved from "https://proteopedia.org/8ou2"