8smn: Difference between revisions
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==Xenopus laevis hyaluronan synthase 1, nascent HA polymer bound state== | |||
<StructureSection load='8smn' size='340' side='right'caption='[[8smn]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8smn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SMN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8smn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8smn OCA], [https://pdbe.org/8smn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8smn RCSB], [https://www.ebi.ac.uk/pdbsum/8smn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8smn ProSAT]</span></td></tr> | ||
[[Category: Gorniak | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HYAS1_XENLA HYAS1_XENLA] Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.<ref>PMID:3410156</ref> <ref>PMID:9442026</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Gorniak I]] | |||
[[Category: Zimmer J]] | |||
Revision as of 06:22, 1 May 2024
Xenopus laevis hyaluronan synthase 1, nascent HA polymer bound state
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