8x7z: Difference between revisions

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'''Unreleased structure'''


The entry 8x7z is ON HOLD
==Crystal structure of CCoV-HuPn-2018 fusion core==
 
<StructureSection load='8x7z' size='340' side='right'caption='[[8x7z]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Lei, Y., Guang, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8x7z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Coronaviridae Coronaviridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X7Z FirstGlance]. <br>
Description: Crystal structure of CCoV-HuPn-2018 fusion core
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x7z OCA], [https://pdbe.org/8x7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x7z RCSB], [https://www.ebi.ac.uk/pdbsum/8x7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x7z ProSAT]</span></td></tr>
[[Category: Lei, Y]]
</table>
[[Category: Guang, Y]]
== Function ==
[https://www.uniprot.org/uniprot/A0A8E6CMP0_9ALPC A0A8E6CMP0_9ALPC] S1 region attaches the virion to the cell membrane by interacting with the host receptor, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04200]
__TOC__
</StructureSection>
[[Category: Coronaviridae]]
[[Category: Large Structures]]
[[Category: Yan L]]
[[Category: Yang G]]
Retrieved from "https://proteopedia.org/8x7z"