2bm4: Difference between revisions

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<StructureSection load='2bm4' size='340' side='right'caption='[[2bm4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2bm4' size='340' side='right'caption='[[2bm4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bm4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BM4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bm4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BM4 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bm5|2bm5]], [[2bm6|2bm6]], [[2bm7|2bm7]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bm4 OCA], [https://pdbe.org/2bm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bm4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bm4 OCA], [https://pdbe.org/2bm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bm4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O50390_MYCTO O50390_MYCTO]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bm4 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bm4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Fluoroquinolones are gaining increasing importance in the treatment of tuberculosis. The expression of MfpA, a member of the pentapeptide repeat family of proteins from Mycobacterium tuberculosis, causes resistance to ciprofloxacin and sparfloxacin. This protein binds to DNA gyrase and inhibits its activity. Its three-dimensional structure reveals a fold, which we have named the right-handed quadrilateral beta helix, that exhibits size, shape, and electrostatic similarity to B-form DNA. This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo.
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.,Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS Science. 2005 Jun 3;308(5727):1480-3. PMID:15933203<ref>PMID:15933203</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2bm4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Blanchard, J S]]
[[Category: Blanchard JS]]
[[Category: Hegde, S S]]
[[Category: Hegde SS]]
[[Category: Maxwell, A]]
[[Category: Maxwell A]]
[[Category: Mitchenall, L A]]
[[Category: Mitchenall LA]]
[[Category: Roderick, S L]]
[[Category: Roderick SL]]
[[Category: Takiff, H E]]
[[Category: Takiff HE]]
[[Category: Vetting, M W]]
[[Category: Vetting MW]]
[[Category: Dna gyrase]]
[[Category: Dna mimicry]]
[[Category: Fluroquinolone resistance]]
[[Category: Pentapeptide repeat protein]]
[[Category: Right-handed quadrilateral beta-helix]]
Retrieved from "https://proteopedia.org/2bm4"