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==Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping==
==Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping==
<StructureSection load='2jwe' size='340' side='right'caption='[[2jwe]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2jwe' size='340' side='right'caption='[[2jwe]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWE FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWE FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwe OCA], [https://pdbe.org/2jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwe RCSB], [https://www.ebi.ac.uk/pdbsum/2jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwe ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwe OCA], [https://pdbe.org/2jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwe RCSB], [https://www.ebi.ac.uk/pdbsum/2jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ji, P]]
[[Category: Ji P]]
[[Category: Shi, Y Y]]
[[Category: Shi YY]]
[[Category: Wu, J H]]
[[Category: Wu JH]]
[[Category: Wu, J W]]
[[Category: Wu JW]]
[[Category: Yang, Y S]]
[[Category: Yang YS]]
[[Category: Zhang, J H]]
[[Category: Zhang JH]]
[[Category: Cell adhesion]]
[[Category: Cell junction]]
[[Category: Dimer]]
[[Category: Domain swapping]]
[[Category: Membrane]]
[[Category: Phosphorylation]]
[[Category: Sh3 domain]]
[[Category: Tight junction]]
[[Category: Tjp1]]
[[Category: Zo-1]]
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