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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kf7 OCA], [https://pdbe.org/2kf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kf7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kf7 ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kf7 OCA], [https://pdbe.org/2kf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kf7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kf7 ProSAT]</span></td></tr> |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Previously, it has been reported that human telomeric DNA sequences could adopt in different experimental conditions four different intramolecular G-quadruplexes each involving three G-tetrad layers, namely, Na(+) solution antiparallel-stranded basket form, K(+) crystal parallel-stranded propeller form, K(+) solution (3 + 1) Form 1, and K(+) solution (3 + 1) Form 2. Here we present a new intramolecular G-quadruplex adopted by a four-repeat human telomeric sequence in K(+) solution (Form 3). This structure is a basket-type G-quadruplex with only two G-tetrad layers: loops are successively edgewise, diagonal, and edgewise; glycosidic conformations of guanines are syn*syn*anti*anti around each tetrad. Each strand of the core has both a parallel and an antiparallel adjacent strands; there are one narrow, one wide, and two medium grooves. Despite the presence of only two G-tetrads in the core, this structure is more stable than the three-G-tetrad intramolecular G-quadruplexes previously observed for human telomeric sequences in K(+) solution. Detailed structural elucidation of Form 3 revealed extensive base pairing and stacking in the loops capping both ends of the G-tetrad core, which might explain the high stability of the structure. This novel structure highlights the conformational heterogeneity of human telomeric DNA. It establishes a new folding principle for G-quadruplexes and suggests new loop sequences and structures for targeting in human telomeric DNA.
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| Structure of the Human Telomere in K(+) Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers.,Lim KW, Amrane S, Bouaziz S, Xu W, Mu Y, Patel DJ, Luu KN, Phan AT J Am Chem Soc. 2009 Mar 9. PMID:19271707<ref>PMID:19271707</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 2kf7" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
