2kg7: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,097 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,097 edits
No edit summary
 
Line 1: Line 1:


==Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288==
==Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288==
<StructureSection load='2kg7' size='340' side='right'caption='[[2kg7]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
<StructureSection load='2kg7' size='340' side='right'caption='[[2kg7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KG7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KG7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">esxG, MT0300, Rv0287 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), esxH, cfp7, Rv0288, MT0301, MTV035.16 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg7 OCA], [https://pdbe.org/2kg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg7 OCA], [https://pdbe.org/2kg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ESXG_MYCTU ESXG_MYCTU] EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol.<ref>PMID:24204276</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 17: Line 19:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kg7 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kg7 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Carr, M D]]
[[Category: Carr MD]]
[[Category: Ilghari, D]]
[[Category: Ilghari D]]
[[Category: Kirsty, L L]]
[[Category: Kirsty LL]]
[[Category: Philip, R S]]
[[Category: Philip RS]]
[[Category: Veverka, V L]]
[[Category: Veverka VL]]
[[Category: Waters, L C]]
[[Category: Waters LC]]
[[Category: Protein complex]]
[[Category: Unknown function]]
Retrieved from "https://proteopedia.org/2kg7"