2kp7: Difference between revisions
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==Solution NMR structure of the Mus81 N-terminal HhH. Northeast Structural Genomics Consortium target MmT1A== | ==Solution NMR structure of the Mus81 N-terminal HhH. Northeast Structural Genomics Consortium target MmT1A== | ||
<StructureSection load='2kp7' size='340' side='right'caption='[[2kp7 | <StructureSection load='2kp7' size='340' side='right'caption='[[2kp7]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kp7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2kp7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KP7 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kp7 OCA], [https://pdbe.org/2kp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kp7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kp7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kp7 OCA], [https://pdbe.org/2kp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kp7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kp7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/MUS81_MOUSE MUS81_MOUSE] Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:14609959</ref> <ref>PMID:15205536</ref> <ref>PMID:16107704</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Laister | [[Category: Laister RC]] | ||
[[Category: Lemak | [[Category: Lemak A]] | ||
[[Category: Montelione | [[Category: Montelione GT]] | ||
[[Category: Wu B]] | |||
[[Category: Wu | |||
Latest revision as of 06:47, 1 May 2024
Solution NMR structure of the Mus81 N-terminal HhH. Northeast Structural Genomics Consortium target MmT1A
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