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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqg OCA], [https://pdbe.org/2kqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqg RCSB], [https://www.ebi.ac.uk/pdbsum/2kqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqg OCA], [https://pdbe.org/2kqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqg RCSB], [https://www.ebi.ac.uk/pdbsum/2kqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqg ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Guanine-rich DNA sequences with the ability to form quadruplex structures are enriched in the promoter regions of protein-coding genes, particularly those of proto-oncogenes. G-quadruplexes are structurally polymorphic and their folding topologies can depend on the sample conditions. We report here on a structural study using solution state NMR spectroscopy of a second G-quadruplex-forming motif (c-kit2) that has been recently identified in the promoter region of the c-kit oncogene. In the presence of potassium ions, c-kit2 exists as an ensemble of structures that share the same parallel-stranded propeller-type conformations. Subtle differences in structural dynamics have been identified using hydrogen-deuterium exchange experiments by NMR spectroscopy, suggesting the coexistence of at least two structurally similar but dynamically distinct substates, which undergo slow interconversion on the NMR timescale.
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.,Hsu ST, Varnai P, Bugaut A, Reszka AP, Neidle S, Balasubramanian S J Am Chem Soc. 2009 Sep 23;131(37):13399-409. PMID:19705869<ref>PMID:19705869</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2kqg" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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Latest revision as of 06:47, 1 May 2024

A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics

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