2kw3: Difference between revisions
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==Heterotrimeric interaction between RFX5 and RFXAP== | ==Heterotrimeric interaction between RFX5 and RFXAP== | ||
<StructureSection load='2kw3' size='340' side='right'caption='[[2kw3 | <StructureSection load='2kw3' size='340' side='right'caption='[[2kw3]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kw3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2kw3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KW3 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kw3 OCA], [https://pdbe.org/2kw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2kw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kw3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kw3 OCA], [https://pdbe.org/2kw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2kw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kw3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/RFX5_HUMAN RFX5_HUMAN] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RFX5_HUMAN RFX5_HUMAN] Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Boss | [[Category: Boss JM]] | ||
[[Category: Briggs | [[Category: Briggs LL]] | ||
[[Category: Garvie | [[Category: Garvie CW]] | ||
[[Category: Laird | [[Category: Laird KM]] | ||
[[Category: Summers | [[Category: Summers MF]] | ||
Latest revision as of 06:49, 1 May 2024
Heterotrimeric interaction between RFX5 and RFXAP
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